Traumatic Brain Injury Blog


Proving TBI

October 24, 2013

Classifying TBI as Mild, Moderate or Severe is Outdated and Counterproductive

The August issue of the Journal of the American Medical Association (JAMA) includes a “Viewpoint” by two leading neuroscientists promoting the use of an “International Knowledge-Based Approach” to traumatic brain injury (TBI).

One of the causes of the failure of clinical trials to successfully treat TBI, the authors contend, is the common classification of TBIs as “mild, moderate or severe.”  These classifications do not incorporate newer insights and findings from diagnostic tools such as imaging and biomarkers and therefore do not promote “mechanistic targeting” for clinical trials. The authors support the transition to a more nuanced approach, a precise disease classification model that is based on the precise pathoanatomical and molecular features of the injury.  Read More

September 25, 2013

Flaws in the Defense Case that mTBI has no Lasting Effect: The Problem with Meta-analysis

Defense attorneys often cite “meta-analytic” reviews of neurological studies to make the argument that “mild” traumatic brain injuries (mTBIs)  cause no lasting effect beyond three months post-injury.  A “meta-analysis” involves a statistical study of multiple studies published in the literature. 

Meta-analyses in mTBI are often used to show that persistent symptoms are “neurotic” rather than “organic”

Fortunately, it is generally agreed that the majority of people who suffer mTBIs, sometimes referred to as “concussions”, report full recovery from symptoms within three months of the injury – in fact many recover much faster. A great deal of research over the past few years has focused on the minority of people who do not fully recover within three months, described as having a “persistent post-concussion symptoms (PCS).”  These patients are sometimes referred to as the “miserable minority.” The “meta-analyses” are often cited as demonstrating that changes in performance after three months have “limited statistical and clinical significance;” in other words, that persistent symptoms must be psychological or “neurotic” rather than “organic” or neurologic. Read More

August 1, 2013

Important New Guidelines on Neuroimaging in Mild Traumatic Brain Injury

In July, 2013 the Defense Centers of Excellence, serving the United States Department of Defense, issued important new guidelines for neuroimaging following “mild” traumatic brain injury.  The guidelines begin with the well-accepted understanding that neuroimaging is not typically included in the diagnosis of mild traumatic brain injury(“mTBI”) because only 10-15% of people who sustain trauma resulting in mTBI will have an acute brain lesion on CT (computed tomography) scans. “The lack of positive imaging findings,” the guidelines emphasize, “does not invalidate a diagnosis of mTBI.”

What is significant about the guidelines is that they recommend imaging in mTBI cases where the victim has “new, persistent or worsening symptoms” 90 days or more following the injury (described as the “chronic stage.”) Read More

June 27, 2013

Progress on Proving Mild Traumatic Brain Injury Using Biomarkers

Concussion, or mild traumatic brain injury (TBI), typically produces no gross pathology, such as hemorrhage or abnormalities, that can be seen on conventional CT scans of the brain. It does cause rapid-onset neurophysiological and neurological dysfunction that in most patients resolves spontaneously over a fairly short period of time. Studies have shown, however, that approximately 15% of individuals with mild TBI develop persistent cognitive dysfunction and other symptoms.  Researchers are starting to make progress on proving mild traumatic brain injury using the biomarkers that underlie such symptoms.  Read More

May 30, 2013

Study Shows Brain Atrophy following “Mild” Traumatic Brain Injury

Further evidence that the term “mild” should never be used in connection with brain injury can be found in a study published in the March 2013 issue of the Journal Radiology

In the study, NYU medical school researchers measured changes in global and regional brain volume over a one year period in 30 patients with “mild” traumatic brain injuries and typical post-injury symptoms including anxiety, depression and fatigue, and other symptoms such as headache, dizziness and perceived cognitive problems. 

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May 9, 2013

The “Show Me” Jury Challenge | Proving TBI to a jury

We live in a world of “show me” juries, programmed to believe that most people bringing personal injury claims to trial are trying to get something for nothing. They want to be convincingly shown that a real injury exists—that the injured person can prove a brain injury or other debilitating condition.

Proving a Mild Traumatic Brain Injury to a Jury

For example, some brain injuries produce bleeding in the brain that clearly shows up on conventional diagnostic images like CT scans—computerized tomography that combines a series of X-ray views taken from many different angles and processed by a computer to create cross-sectional images of the bones and soft tissues inside your body—and/or MRIs—magnetic resonance imaging that uses a magnetic field and radio waves to create detailed images of the organs and tissues within your body—or, that produce visible  neurological signs like seizures,  visual problems, speech problems, or motor problems.

Proving a brain injury to a jury where visible evidence is available is not difficult. However, we know that many mild traumatic brain injuries are “invisible” to these standard tests, yet are serious enough to greatly impact quality of life. In these cases, the challenge is to help the jury understand those long-term consequences, even when the injury is not visible.

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