Traumatic Brain Injury Blog


Tagged with “meta-analysis”

September 25, 2013

Flaws in the Defense Case that mTBI has no Lasting Effect: The Problem with Meta-analysis

Defense attorneys often cite “meta-analytic” reviews of neurological studies to make the argument that “mild” traumatic brain injuries (mTBIs)  cause no lasting effect beyond three months post-injury.  A “meta-analysis” involves a statistical study of multiple studies published in the literature. 

Meta-analyses in mTBI are often used to show that persistent symptoms are “neurotic” rather than “organic”

Fortunately, it is generally agreed that the majority of people who suffer mTBIs, sometimes referred to as “concussions”, report full recovery from symptoms within three months of the injury – in fact many recover much faster. A great deal of research over the past few years has focused on the minority of people who do not fully recover within three months, described as having a “persistent post-concussion symptoms (PCS).”  These patients are sometimes referred to as the “miserable minority.” The “meta-analyses” are often cited as demonstrating that changes in performance after three months have “limited statistical and clinical significance;” in other words, that persistent symptoms must be psychological or “neurotic” rather than “organic” or neurologic. Read More