In a peer-reviewed article published in the Journal of Alzheimer’s Disease, 2020;78(2):757-775. doi: 10.3233/JAD-200662, Canadian researcher found that a history of mild traumatic brain injury (mTBI) almost doubled the risk of being diagnosed with dementia and that mTBI was the strongest environmental risk factor for dementia, comparable to health risk factors such as diabetes, hypertension and obesity. Read More
In a propensity-matched cohort study of more than 350,000 veterans with and without traumatic brain injuries (TBI), mild traumatic brain injury (mTBI) without loss of consciousness was associated with more than a twofold increase in the risk of a dementia diagnosis, even after adjusting for medical and psychiatric co-morbidities. This large epidemiological study was recently published in JAMA Neurology. Approximately 2.8 million TBIs occur each year in the United States; approximately 80% are in the “mild” category.
Although prior studies of the association between mTBI and dementia have been mixed, this study, among the largest epidemiological studies to date, adds to the weight of evidence suggesting that even mild TBI is associated with an increased dementia diagnosis risk. Read More
The latest issue of the Journal of Neuroscience (April 22, 2015) reports on animal research from the University of Kentucky which “adds to an increasing body of knowledge strongly indicating that traumatic brain injury is a contributor to increased susceptibility to Alzheimer’s Disease-relevant pathologies, including cognitive dysfunction.”
The authors begin by noting that “epidemiological studies have associated increased risk of Alzheimer’s disease-related clinical symptoms with a medical history of head injury,” but that “little is known about the pathophysiological mechanisms linked to this association.” Prior studies, as well as this study, did find that persistent neuroinflammation is one outcome observed in patients after a single head injury. Read More