Traumatic Brain Injury Blog

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Tagged with “DAMPS”

September 17, 2020

Damage to the Brain’s Lymphatic System May Explain Why Some Patients Suffer More Serious Consequences from TBI

Studies over the last several years have shown that the lymphatic system serving the brain, located in the membranes covering the brain (the “meninges”) plays an important role in brain injury recovery.

As most people know, the lymphatic system helps to rid the body of toxins and waste, including the byproducts of the body’s immune response to injury. For brain injury this is sometimes described as “damage/danger-associated molecular patterns” – “DAMPs” – such as protein aggregates, necrotic cells, and cellular debris.

Researchers at the University of Virginia, at the Center for Brain Immunology and Glia, have released an important study furthering our understanding of the role meningeal lymphatic dysfunction plays in causing some patients to suffer severe and long-lasting impairments following even a “mild” traumatic brain injury (TBI) and helps to explain why these injuries increase the risk for neurodegenerative problems such as Alzheimer’s, ALS and dementia. Read More