Concussion May Triple the Risk of Suicide
Researchers at the University of Toronto have released the results of a study of the incidence of suicide in 236,000 concussion patients followed over a 20 year period. Read More
Rehabilitation
Neuroinflammation and TBI: Research Leads to Anti-inflammatory Lifestyle Strategies
Neuroinflammation as a likely cause of persistent symptoms following traumatic brain injury (TBI), as well as increased risk of neurodegenerative complications, is leading to increased attention on anti-inflammatory strategies with diet, exercise, lifestyle and medication
Our May 28, 2015 blog post discussed the evidence offered by McMasters University researchers in support of their conclusion that the body’s immune response following injury can lead to unchecked, ultimately destructive neuroinflammation and that this likely underlies persistent symptoms following TBI as well as increased risk of neurodegenerative conditions such as chronic traumatic encephalopathy (CTE) and Alzheimers. The authors observed similar neuroinflammatory processes in patients without a history of head injury, such as patients with serious infections, PTSD and Depression. They also noted that subtle genetic differences may explain differences in inflammatory responses between patients, leading to different long term outcomes. The October 2015 issue of Trends in Neuroscience includes a review by Ohio State neuroscientists with further support for this new paradigm for understanding the brain’s response to injury. See “Priming the Inflammatory Pump of the CNS after Traumatic Brain Injury.” Read More
Study Links Tau Protein with Persistent Post-Concussive Symptoms
Research from the National Institute of Health, published in the August 3, 2015 issue of JAMA Neurology, shows that a protein that was until recently linked only to acute symptoms following traumatic brain injury, may also be responsible for chronic neurological symptoms, such as headache and dizziness, found in patients diagnosed with persistent post-concussion syndrome.
Tau is a protein known to play a significant role in the development of Alzheimer’s disease and Parkinson’s disease. Using ultra-sensitive technology, the researchers measured levels of tau in the blood months and years after injury. These levels correlated with the severity of post-concussive symptoms. If these findings are further confirmed, this could be the first biomarker that is sensitive and specific to ongoing TBI symptoms. Read More
A New Paradigm for Understanding Incapacitating Post-Concussion Syndrome
In a study published in April 2015 in the medical journal Brain Behavior and Immunity, a team of Canadian researchers at McMaster University presents a new understanding of the cause of the wide-array of symptoms experienced by some patients following concussion, such as headaches, dizziness, sleep disturbance, fatigue, cognitive impairment and neuropsychiatric symptoms.
This new paradigm helps to explain why the same pattern of symptoms can be found in some non-head injury patients, such a patient who has experienced infections or a patient diagnosed with post-traumatic stress disorder. It also helps to explain why some patients recover and others do not and why pre-accident experience can influence the course of post-accident recovery. Read More
The Promise of An Effective Drug Treatment for TBI
Researchers at the Henry Ford Neuroscience Institute, a leading neuroscience research facility, recently announced the results of research showing that the only drug currently approved to treat the crippling effects of stroke shows promise, when administered as a nasal spray, to help heal the effects of less severe forms of traumatic brain injury. This is exciting news, since researchers have been struggling unsuccessfully for years to find an effective drug treatment for TBI. The research results are based on animal studies, so further work will be needed to determine the best dose and window for administration in humans. Read More
More Encouraging News Concerning the Recognition and Treatment of Concussion and Mild Traumatic Brain Injury
Several recent developments demonstrate increasing recognition of the serious potential consequences of concussion, and commitment to minimize those consequences through appropriate treatment of concussion:
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Physicians have an ethical obligation to become knowledgeable about concussion.
On June 9, 2014 the American Academy of Neurology, the largest professional association of neurologists, released a position paper stating that doctors have an ethical obligation to educate and protect athletes from sports concussion and clear them to play only when the athlete is medically ready, standing firm against objections from players, athletes and coaches. The statement declares that sports concussion “is a major issue in the world of health care” and requires more attention from physicians. Read More
Concussion as a Medical Diagnosis
Different symptom patterns of concussion depend on the precise nature of the damage to the brain
Medical research is increasingly identifying the various ways a concussion can impact the brain and is providing explanations for why different symptoms persist in a subset of people diagnosed with concussion, based on the anatomy and physiology of the brain.
Much of this recent research has benefited from new techniques to “image” the brain, including various MRI techniques such as “diffusion tensor imaging” (“DTI”). In a prior post, I discussed research concerning the subset of concussed patients who experience persistent ocular (vision) and vestibular (balance) problems. A paper published online on April 15, 2014 in the journal Radiology reported that DTI imaging of patients with these symptoms revealed damage in the parts of the brain know to be associated with vision and balance. Read More
Neuroendocrine Dysfunction following Traumatic Brain Injury: Could This be a Key to More Successful Treatment?
Recent research has shown that traumatic brain injury, (TBI) including mild traumatic brain injury (mTBI), can damage and cause dysfunction in the pituitary gland, a pea-sized gland located in the center of the skull that releases several essential hormones affecting such functions as growth and metabolism (part of the neuroendocrine system). Researchers have found that a surprisingly high percentage of patients with persistent symptoms following a TBI show evidence of neuroendocrine dysfunction.
It turns out that the anatomy of this gland makes it particularly susceptible to the sheering injuries seen in TBI. The most common dysfunction found after TBI is deficiency in the Growth Hormone (GH), one of the key hormones released by the pituitary gland. The symptoms of GH deficiency overlap with many persistent TBI symptoms including fatigue, poor memory, depression, emotional lability, lack of concentration and attention difficulties. Read More
New Data Supports Importance of Cognitive Rest for Concussion Recovery
Most current guidelines recommend “cognitive rest” during the initial stages of recovery from concussion. “Cognitive rest” involves limiting activities that require attention and concentration such as reading, doing homework, text messaging, playing video games, working online, watching movies and television and listening to music. Cognitive rest has been recommended in the past based on somewhat limited evidence suggesting that failing to minimize these activities in the early stages following a concussion could delay recovery. Read More
“Unprecedented breakthrough” offers potential for recovery from paralysis
Scientists announce dramatic research where epidural stimulation offers potential for recovery from paralysis following spinal cord injury
Nearly six million Americans are living with paralysis, including 1.275 million spinal cord injuries. Most have been told that no recovery is possible and that complete paralysis is permanent. This belief was fundamentally challenged with the announcement on April 8, 2014 by international team of scientists at the University of Louisville, UCLA and the Pavlov Institute of Physiology, that four young men who had been paralyzed for years were able to voluntarily move their hips, ankles and toes following the implantation of an epidural electrical stimulator. These results were published in journal Brain. Read More